Effect of Gold Nanoparticles on Dose Enhancement of 6 MV X-ray in MAGIC_f Polymer Gel Dosimeter

S F Ghoreishi, J Beik, I Shiri, K Kh Keshavarzi, S R M Mahdavi

Abstract


Background:Currently, the potential application of gold nanoparticles (AuNPs) to increase the efficiency of radiation therapy has been widely investigated. However, lack of an appropriate method to estimate the dose distribution in a nanoparticle-laden tissue limits the applicability of nanoparticles in radiotherapy clinics. Polymer gel dosimetry provides an accurate and precise system that facilitates the measurement of dose distribution in full three dimensions.

Objective: In this study, the effect of radiation dose enhancement of AuNPs was assessed through gel dosimetry analysis.

Material and Methods: For this purpose, AuNPs were integrated in MAGIC_f polymer gel dosimeter and irradiated by 6 Mv X-ray beam. The irradiated gel was then evaluated through two modalities of magnetic resonance imaging (MRI) and optical computed tomography (OCT).

Result: MRI and OCT scanning of MAGIC_f gels containing 0.1 mM AuNPs demonstrated dose enhancements of 7.8% and 6.8%, respectively.

Conclusion: Polymer gel dosimetry has the potential to provide a new platform for the investigation and optimization of the applicability of nanoparticles in radiation therapy.


Keywords


Radiation Therapy, Gold Nanoparticles, Polymer Gel Dosimetry, Optical Computed Tomography

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DOI: https://doi.org/10.31661/jbpe.v0i0.693

eISSN: 2251-7200        JBPE NLM ID: 101589641

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